Islet-endogenous and exogenous IL-22, by regulating oxidative stress pathways, suppresses oxidative and ER stress caused by cytokines or glucolipotoxicity in pancreatic beta cells.

Our findings attribute a regulatory role for endogenous pancreatic beta-cell IL-22ra1 in insulin secretion, islet regeneration, inflammation/cellular stress and appropriate systemic metabolic regulation.

Interleukin-22 suppresses major histocompatibility complex II in mucosal epithelial cells

These short-acting IL-22-bispecific targeted biologics are a promising new therapeutic approach for MASH. Treatment restores glycemic control, markedly reduces hepatic steatosis, inflammation, and fibrogenesis.

In this review, we highlight the dynamic function of the mucins and mucus during infection, how this mucosal barrier is regulated, and how pathogens have evolved mechanisms to evade this defence system

Goblet cells potentially act as sentinel cells and we comment on how this is potentially regulated.

Publication focussing on the complex relationship between an epithelial cell defect, microbiome translocation and mucosal inflammation.

Production of cytokines is beneficial for anti-viral responses; however, prolonged production further induces protein misfolding and leads to a cycle of stress and inflammation in the absence of pathogens.

In epithelial cells, STAT3 activation induced by IL-22 modulates antimicrobial and mucin secretion to maintain epithelial cell barrier integrity.